Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus

Chembiochem. 2013 May 27;14(8):938-42. doi: 10.1002/cbic.201300070. Epub 2013 May 6.

Abstract

Stimulating encounter: The intimate, physical interaction between the soil-derived bacterium Streptomyces rapamycinicus and the human pathogenic fungus Aspergillus fumigatus led to the activation of an otherwise silent polyketide synthase (PKS) gene cluster coding for an unusual prenylated polyphenol (fumicycline A). The meroterpenoid pathway is regulated by a pathway-specific activator gene as well as by epigenetic factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aspergillus fumigatus / genetics
  • Aspergillus fumigatus / physiology*
  • Coculture Techniques
  • Gene Expression Regulation, Fungal*
  • Models, Molecular
  • Multigene Family
  • Polyketide Synthases / genetics*
  • Polyketide Synthases / metabolism
  • Polyketides / metabolism
  • Polyphenols / metabolism
  • Signal Transduction
  • Streptomyces / physiology*

Substances

  • Polyketides
  • Polyphenols
  • Polyketide Synthases