Abstract
Lineage decisions in development are thought to be primarily due to differential activation of transcription factors. However, cell position and subcellular organization of signalling also play a role. New studies of the Hippo pathway in the early mouse embryo show how.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics*
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Angiomotins
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Animals
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Blastocyst / metabolism*
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Cell Cycle Proteins
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Cell Polarity*
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Gene Expression Regulation, Developmental*
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Hippo Signaling Pathway
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Intercellular Signaling Peptides and Proteins / genetics*
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Microfilament Proteins / genetics*
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Neurofibromin 2 / genetics*
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Phosphoproteins / genetics*
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Protein Serine-Threonine Kinases / genetics*
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Signal Transduction*
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YAP-Signaling Proteins
Substances
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Adaptor Proteins, Signal Transducing
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Amot protein, mouse
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Angiomotins
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Cell Cycle Proteins
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Intercellular Signaling Peptides and Proteins
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Microfilament Proteins
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Neurofibromin 2
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Phosphoproteins
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YAP-Signaling Proteins
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Yap1 protein, mouse
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Protein Serine-Threonine Kinases