Development: Hippo signalling turns the embryo inside out

Curr Biol. 2013 Jul 8;23(13):R559-61. doi: 10.1016/j.cub.2013.05.064.

Abstract

Lineage decisions in development are thought to be primarily due to differential activation of transcription factors. However, cell position and subcellular organization of signalling also play a role. New studies of the Hippo pathway in the early mouse embryo show how.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Angiomotins
  • Animals
  • Blastocyst / metabolism*
  • Cell Cycle Proteins
  • Cell Polarity*
  • Gene Expression Regulation, Developmental*
  • Hippo Signaling Pathway
  • Intercellular Signaling Peptides and Proteins / genetics*
  • Microfilament Proteins / genetics*
  • Neurofibromin 2 / genetics*
  • Phosphoproteins / genetics*
  • Protein Serine-Threonine Kinases / genetics*
  • Signal Transduction*
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Amot protein, mouse
  • Angiomotins
  • Cell Cycle Proteins
  • Intercellular Signaling Peptides and Proteins
  • Microfilament Proteins
  • Neurofibromin 2
  • Phosphoproteins
  • YAP-Signaling Proteins
  • Yap1 protein, mouse
  • Protein Serine-Threonine Kinases