Direct recordings of grid-like neuronal activity in human spatial navigation

Nat Neurosci. 2013 Sep;16(9):1188-90. doi: 10.1038/nn.3466. Epub 2013 Aug 4.

Abstract

Grid cells in the entorhinal cortex appear to represent spatial location via a triangular coordinate system. Such cells, which have been identified in rats, bats and monkeys, are believed to support a wide range of spatial behaviors. Recording neuronal activity from neurosurgical patients performing a virtual-navigation task, we identified cells exhibiting grid-like spiking patterns in the human brain, suggesting that humans and simpler animals rely on homologous spatial-coding schemes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Action Potentials / physiology
  • Brain Mapping*
  • Entorhinal Cortex / cytology*
  • Entorhinal Cortex / diagnostic imaging
  • Entorhinal Cortex / pathology
  • Epilepsy / pathology
  • Epilepsy / surgery
  • Humans
  • Image Processing, Computer-Assisted
  • Magnetic Resonance Imaging
  • Models, Neurological
  • Movement
  • Neurons / physiology*
  • Space Perception / physiology*
  • Spatial Behavior / physiology*
  • Tomography, X-Ray Computed
  • User-Computer Interface