Single glutamate to aspartate mutation makes ferric uptake regulator (Fur) as sensitive to H2O2 as peroxide resistance regulator (PerR)

Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10339-43. doi: 10.1002/anie.201304021. Epub 2013 Aug 12.

Authors

Aubérie Parent¹, Christelle Caux-Thang, Luca Signor, Martin Clémancey, Ramakrishnan Sethu, Geneviève Blondin, Pascale Maldivi, Victor Duarte, Jean-Marc Latour

Affiliation

¹ Univ. Grenoble Alpes, LCBM, 38054 Grenoble (France); CEA, DSV, iRTSV, LCBM, PMB, 38054 Grenoble (France); CNRS UMR 5249, LCBM, 38054 Grenoble (France).

PMID: 23940006
DOI: 10.1002/anie.201304021

No abstract available

Keywords: Mössbauer spectroscopy; density functional calculations; ferric uptake regulator; peroxide resistance regulator; peroxide stress.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Aspartic Acid / chemistry
Aspartic Acid / genetics
Aspartic Acid / metabolism
Bacteria / chemistry
Bacteria / genetics
Bacteria / metabolism*
Bacterial Proteins / chemistry
Bacterial Proteins / genetics
Bacterial Proteins / metabolism*
Glutamic Acid / chemistry
Glutamic Acid / genetics
Glutamic Acid / metabolism
Humans
Hydrogen Peroxide / metabolism*
Models, Molecular
Molecular Sequence Data
Point Mutation
Repressor Proteins / chemistry
Repressor Proteins / genetics
Repressor Proteins / metabolism*
Sequence Alignment
Spectroscopy, Mossbauer

Substances

Bacterial Proteins
Repressor Proteins
ferric uptake regulating proteins, bacterial
peroxide repressor proteins
Aspartic Acid
Glutamic Acid
Hydrogen Peroxide