Abstract
Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity. Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it provides a mechanism for the elimination of intracellular microorganisms. Autophagy controls inflammation through regulatory interactions with innate immune signalling pathways, by removing endogenous inflammasome agonists and through effects on the secretion of immune mediators. Moreover, autophagy contributes to antigen presentation and to T cell homeostasis, and it affects T cell repertoires and polarization. Thus, as we discuss in this Review, autophagy has multitiered immunological functions that influence infection, inflammation and immunity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / genetics
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Adaptor Proteins, Signal Transducing / immunology
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Antigen Presentation
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Autophagy / genetics
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Autophagy / immunology*
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Bacterial Infections / genetics
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Bacterial Infections / immunology*
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Bacterial Infections / metabolism
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Gene Expression Regulation
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Homeostasis
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Humans
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Immunity, Innate*
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Inflammasomes / genetics
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Inflammasomes / immunology
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Inflammation
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Protein Transport
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Receptors, Pattern Recognition / genetics
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Receptors, Pattern Recognition / immunology*
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Signal Transduction
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T-Lymphocytes / immunology
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T-Lymphocytes / microbiology
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T-Lymphocytes / virology
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Virus Diseases / genetics
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Virus Diseases / immunology*
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Virus Diseases / metabolism
Substances
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Adaptor Proteins, Signal Transducing
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Inflammasomes
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Receptors, Pattern Recognition