Increased prevalence of aminoglycoside resistance in clinical isolates of Escherichia coli and Klebsiella spp. in Norway is associated with the acquisition of AAC(3)-II and AAC(6')-Ib

Bjørg C Haldorsen; Gunnar Skov Simonsen; Arnfinn Sundsfjord; Orjan Samuelsen; Norwegian Study Group on Aminoglycoside Resistance

doi:10.1016/j.diagmicrobio.2013.10.001

Increased prevalence of aminoglycoside resistance in clinical isolates of Escherichia coli and Klebsiella spp. in Norway is associated with the acquisition of AAC(3)-II and AAC(6')-Ib

Diagn Microbiol Infect Dis. 2014 Jan;78(1):66-9. doi: 10.1016/j.diagmicrobio.2013.10.001. Epub 2013 Oct 14.

Authors

Bjørg C Haldorsen¹, Gunnar Skov Simonsen², Arnfinn Sundsfjord², Orjan Samuelsen³; Norwegian Study Group on Aminoglycoside Resistance

Affiliations

¹ Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.
² Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway; Research Group for Host-Microbe Interactions, Department of Medical Biology, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
³ Reference Centre for Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway. Electronic address: orjan.samuelsen@unn.no.

PMID: 24231381
DOI: 10.1016/j.diagmicrobio.2013.10.001

Abstract

In this study, we show that the increasing prevalence of aminoglycoside resistance observed in Norway among clinical Escherichia coli and Klebsiella spp. isolates is mainly due to the presence of the aminoglycoside-modifying enzymes AAC(3)-II and AAC(6')-Ib. A frequent co-association of aminoglycoside resistance with Cefotaximase-München group 1 extended-spectrum β-lactamases was also observed.

Keywords: AAC(3)-II; AAC(6′)-Ib; CTX-M; ESBL; RmtB.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetyltransferases / genetics*
Aminoglycosides / pharmacology*
Anti-Bacterial Agents / pharmacology
Drug Resistance, Bacterial*
Escherichia coli / drug effects*
Escherichia coli / enzymology
Escherichia coli / genetics
Escherichia coli / isolation & purification
Escherichia coli Infections / epidemiology*
Escherichia coli Infections / microbiology
Humans
Klebsiella / drug effects*
Klebsiella / enzymology
Klebsiella / genetics
Klebsiella / isolation & purification
Klebsiella Infections / epidemiology*
Klebsiella Infections / microbiology
Norway / epidemiology
Prevalence

Substances

Aminoglycosides
Anti-Bacterial Agents
Acetyltransferases
aminoglycoside acetyltransferase