Abstract
Paired helical filaments (PHF) are unusual neuronal fibers which accumulate progressively in the brain in Alzheimer's disease (AD). The insolubility of PHF in various kinds of solvents enabled us to obtain highly purified PHF, but prevented the application of conventional analytical methods to identify their components. Here we report that antibodies against purified PHF recognize tau protein, a brain-specific microtubule-associated protein, suggesting that a portion of PHF is tau protein.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alzheimer Disease / metabolism*
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Animals
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Brain / embryology
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Brain / ultrastructure
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Brain Chemistry*
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Down Syndrome / metabolism
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Epitopes / analysis*
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Fetus / analysis
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Humans
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Immunochemistry
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Microtubule-Associated Proteins / analysis*
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Microtubule-Associated Proteins / immunology
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Nerve Tissue Proteins / analysis*
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Nerve Tissue Proteins / immunology
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Rats
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tau Proteins
Substances
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Epitopes
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Microtubule-Associated Proteins
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Nerve Tissue Proteins
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tau Proteins