Abstract
Herpesviruses encode membrane-associated G protein-coupled receptors (GPCRs) in their viral genomes that are structurally similar to chemokine receptors. These GPCRs hijack GPCR-mediated cellular signalling networks of the host for survival, replication and pathogenesis. In particular the herpesvirus-encoded chemokine receptors ORF74, BILF1 and US28, which are present at inflammatory sites and tumour cells, provide important virus-specific targets for directed therapies. Given the high druggability of GPCRs in general, these viral GPCRs can be considered promising antiviral drug targets.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Antiviral Agents / therapeutic use
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Cell Proliferation / drug effects
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Herpesviridae / genetics
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Herpesviridae / pathogenicity*
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Herpesviridae Infections / drug therapy
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Herpesviridae Infections / immunology
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Herpesviridae Infections / metabolism*
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Herpesviridae Infections / virology
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Humans
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Protein Binding
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Receptors, Chemokine / genetics*
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Receptors, Chemokine / metabolism
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Receptors, G-Protein-Coupled / genetics*
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Receptors, G-Protein-Coupled / metabolism
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Signal Transduction / drug effects
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Signal Transduction / physiology
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Tumor Virus Infections / drug therapy
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Tumor Virus Infections / immunology
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Tumor Virus Infections / metabolism*
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Tumor Virus Infections / virology
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Viral Proteins / genetics*
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Viral Proteins / metabolism
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Antiviral Agents
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Receptors, Chemokine
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Receptors, G-Protein-Coupled
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Viral Proteins