Do we need a new vaccine to control the re-emergence of pertussis?

Kingston H G Mills; Pádraig J Ross; Aideen C Allen; Mieszko M Wilk

doi:10.1016/j.tim.2013.11.007

Do we need a new vaccine to control the re-emergence of pertussis?

Trends Microbiol. 2014 Feb;22(2):49-52. doi: 10.1016/j.tim.2013.11.007.

Authors

Kingston H G Mills¹, Pádraig J Ross², Aideen C Allen², Mieszko M Wilk²

Affiliations

¹ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland. Electronic address: kingston.mills@tcd.ie.
² School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

PMID: 24485284
DOI: 10.1016/j.tim.2013.11.007

Abstract

Bordetella pertussis causes whooping cough and is re-emerging in developed countries despite widespread immunization with acellular pertussis vaccines (Pa), which are less effective than the whole cell vaccines that they replaced. Efficacy of Pa could be improved by switching from alum to alternative adjuvants that generate more potent cell mediated immunity.

Keywords: Bordetella pertussis; Th1 cell; adjuvant; cell mediated immunity; vaccine; whooping cough.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / administration & dosage
Bordetella pertussis / immunology*
Bordetella pertussis / isolation & purification*
Communicable Diseases, Emerging / epidemiology
Communicable Diseases, Emerging / prevention & control
Humans
Pertussis Vaccine / administration & dosage*
Pertussis Vaccine / immunology*
Vaccination / methods*
Vaccines, Acellular / administration & dosage
Vaccines, Acellular / immunology
Whooping Cough / epidemiology*
Whooping Cough / prevention & control*

Substances

Adjuvants, Immunologic
Pertussis Vaccine
Vaccines, Acellular