Photo-click living strategy for controlled, reversible exchange of biochemical ligands

Adv Mater. 2014 Apr 23;26(16):2521-6. doi: 10.1002/adma.201304847. Epub 2014 Feb 12.

Abstract

A novel addition-fragmentation-chain transfer capable allyl sulfide functionalized PEG hydrogel is reported to allow controlled, reversible exchange of biochemical ligands. The exchange of biochemical ligands is achieved without permanent consumption of reactive functionalities. Demonstrated is the ability to exchange biochemical ligands multiple times using cytocompatible 720 nm two-photon light.

Keywords: addition fragmentation chain transfer; hydrogels; photo-patterning; thiol-ene reaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Allyl Compounds / chemistry
  • Benzoquinones / chemistry
  • Biochemistry / methods*
  • Click Chemistry*
  • Glass / chemistry
  • Humans
  • Hydrogels / chemistry*
  • Kinetics
  • Ligands
  • Photochemical Processes*
  • Polyethylene Glycols / chemistry
  • Streptavidin / chemistry
  • Sulfides / chemistry

Substances

  • Allyl Compounds
  • Benzoquinones
  • Hydrogels
  • Ligands
  • Sulfides
  • quinone
  • Polyethylene Glycols
  • allyl sulfide
  • Streptavidin