A cascade of DNA-binding proteins for sexual commitment and development in Plasmodium

Nature. 2014 Mar 13;507(7491):253-257. doi: 10.1038/nature12970. Epub 2014 Feb 23.

Abstract

Commitment to and completion of sexual development are essential for malaria parasites (protists of the genus Plasmodium) to be transmitted through mosquitoes. The molecular mechanism(s) responsible for commitment have been hitherto unknown. Here we show that PbAP2-G, a conserved member of the apicomplexan AP2 (ApiAP2) family of DNA-binding proteins, is essential for the commitment of asexually replicating forms to sexual development in Plasmodium berghei, a malaria parasite of rodents. PbAP2-G was identified from mutations in its encoding gene, PBANKA_143750, which account for the loss of sexual development frequently observed in parasites transmitted artificially by blood passage. Systematic gene deletion of conserved ApiAP2 genes in Plasmodium confirmed the role of PbAP2-G and revealed a second ApiAP2 member (PBANKA_103430, here termed PbAP2-G2) that significantly modulates but does not abolish gametocytogenesis, indicating that a cascade of ApiAP2 proteins are involved in commitment to the production and maturation of gametocytes. The data suggest a mechanism of commitment to gametocytogenesis in Plasmodium consistent with a positive feedback loop involving PbAP2-G that could be exploited to prevent the transmission of this pernicious parasite.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Culicidae / parasitology
  • DNA-Binding Proteins / deficiency
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Feedback, Physiological
  • Female
  • Gene Expression Regulation
  • Germ Cells / cytology
  • Germ Cells / growth & development*
  • Germ Cells / metabolism
  • Malaria / parasitology*
  • Male
  • Mutation / genetics
  • Plasmodium berghei / cytology
  • Plasmodium berghei / genetics*
  • Plasmodium berghei / physiology*
  • Protein Transport
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism*
  • Reproduction, Asexual
  • Sexual Development / genetics*
  • Transcription, Genetic

Substances

  • DNA-Binding Proteins
  • Protozoan Proteins

Associated data

  • GEO/GSE52859
  • GEO/GSE53246