Statistical mechanics model for the dynamics of collective epigenetic histone modification

Phys Rev Lett. 2014 Feb 14;112(6):068101. doi: 10.1103/PhysRevLett.112.068101. Epub 2014 Feb 10.

Abstract

Epigenetic histone modifications play an important role in the maintenance of different cell phenotypes. The exact molecular mechanism for inheritance of the modification patterns over cell generations remains elusive. We construct a Potts-type model based on experimentally observed nearest-neighbor enzyme lateral interactions and nucleosome covalent modification state biased enzyme recruitment. The model can lead to effective nonlocal interactions among nucleosomes suggested in previous theoretical studies, and epigenetic memory is robustly inheritable against stochastic cellular processes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Epigenomics
  • Histones / genetics*
  • Histones / metabolism
  • Lysine / genetics
  • Lysine / metabolism
  • Methylation
  • Models, Genetic*
  • Models, Statistical
  • Nucleosomes / enzymology
  • Nucleosomes / genetics
  • Nucleosomes / metabolism
  • Octamer Transcription Factor-3 / genetics
  • Stochastic Processes
  • Thermodynamics

Substances

  • Histones
  • Nucleosomes
  • Octamer Transcription Factor-3
  • Lysine