Is DNA methylation of tumour suppressor genes epigenetic?

Elife. 2014 Mar 12:3:e02475. doi: 10.7554/eLife.02475.

Abstract

In colorectal cancer cells, a non-epigenetic transcriptional pathway that is mediated by an oncogene maintains DNA methylation of tumour suppressor genes.

Keywords: CpG island methylator phenotype; DNMT1; INK4-ARF; KRAS; ZNF304; colorectal cancer.

Publication types

  • Comment

MeSH terms

  • Animals
  • CpG Islands*
  • DNA Methylation*
  • Gene Silencing*
  • Genes, ras*
  • Humans
  • Transcription, Genetic*