SMC complexes link gene expression and genome architecture

Jill M Dowen; Richard A Young

doi:10.1016/j.gde.2013.11.009

SMC complexes link gene expression and genome architecture

Curr Opin Genet Dev. 2014 Apr:25:131-7. doi: 10.1016/j.gde.2013.11.009. Epub 2014 May 8.

Authors

Jill M Dowen¹, Richard A Young²

Affiliations

¹ Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States.
² Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, United States; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, United States. Electronic address: young@wi.mit.edu.

Abstract

The structural maintenance of chromosomes (SMC) complexes are associated with transcriptional enhancers, promoters and insulators, where they contribute to the control of gene expression and genome structure. We review here recent insights into the interlinked roles of SMC complexes in gene expression and genome architecture. Among these, we note evidence that SMC complexes play important roles in the regulation of genes that control cell identity. We conclude by reviewing diseases associated with SMC mutations.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Chromosomes / chemistry
Chromosomes / genetics*
Gene Expression Regulation
Gene Expression*
Genome*
Humans
Mutation
Transcription, Genetic

Abstract

Publication types

MeSH terms

Grants and funding