The changing geometry of a fitness landscape along an adaptive walk

PLoS Comput Biol. 2014 May 22;10(5):e1003520. doi: 10.1371/journal.pcbi.1003520. eCollection 2014 May.

Abstract

It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression in NK model fitness landscapes. Here we show that this phenomenon occurs quite generally in fitness landscapes. We propose a simple and general explanation for this phenomenon, confirming the role of mean regression. We provide support for this explanation with simulations, and discuss the empirical relevance of our findings.

MeSH terms

  • Adaptation, Physiological / genetics*
  • Animals
  • Computer Simulation
  • Epistasis, Genetic / genetics*
  • Evolution, Molecular*
  • Genetic Fitness / genetics*
  • Genetics, Population
  • Humans
  • Models, Genetic*
  • Models, Statistical*
  • Selection, Genetic / genetics*

Grants and funding

No specific funding was received for this manuscript.