Regulation of the mammalian elongation cycle by subunit rolling: a eukaryotic-specific ribosome rearrangement

Cell. 2014 Jul 3;158(1):121-31. doi: 10.1016/j.cell.2014.04.044.

Abstract

The extent to which bacterial ribosomes and the significantly larger eukaryotic ribosomes share the same mechanisms of ribosomal elongation is unknown. Here, we present subnanometer resolution cryoelectron microscopy maps of the mammalian 80S ribosome in the posttranslocational state and in complex with the eukaryotic eEF1A⋅Val-tRNA⋅GMPPNP ternary complex, revealing significant differences in the elongation mechanism between bacteria and mammals. Surprisingly, and in contrast to bacterial ribosomes, a rotation of the small subunit around its long axis and orthogonal to the well-known intersubunit rotation distinguishes the posttranslocational state from the classical pretranslocational state ribosome. We term this motion "subunit rolling." Correspondingly, a mammalian decoding complex visualized in substates before and after codon recognition reveals structural distinctions from the bacterial system. These findings suggest how codon recognition leads to GTPase activation in the mammalian system and demonstrate that in mammalia subunit rolling occurs during tRNA selection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Anticodon / metabolism
  • Codon / metabolism
  • Cryoelectron Microscopy
  • Crystallography, X-Ray
  • Humans
  • Mammals / metabolism*
  • Molecular Sequence Data
  • Peptide Chain Elongation, Translational
  • RNA, Transfer / metabolism
  • Rabbits
  • Ribosomes / chemistry*
  • Saccharomyces cerevisiae / metabolism
  • Tetrahymena thermophila / metabolism

Substances

  • Anticodon
  • Codon
  • RNA, Transfer

Associated data

  • PDB/4CXB
  • PDB/4CXC
  • PDB/4CXD
  • PDB/4CXE
  • PDB/4CXG
  • PDB/4CXH