PML, SUMO, and RNF4: guardians of nuclear protein quality

Anne Gärtner; Stefan Muller

doi:10.1016/j.molcel.2014.06.022

PML, SUMO, and RNF4: guardians of nuclear protein quality

Mol Cell. 2014 Jul 3;55(1):1-3. doi: 10.1016/j.molcel.2014.06.022.

Authors

Anne Gärtner¹, Stefan Muller²

Affiliations

¹ Institute of Biochemistry II, Goethe University, Faculty of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.
² Institute of Biochemistry II, Goethe University, Faculty of Medicine, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. Electronic address: ste.mueller@em.uni-frankfurt.de.

PMID: 24996060
DOI: 10.1016/j.molcel.2014.06.022

Abstract

In this issue of Molecular Cell, Guo et al. (2014) report that misfolded or aggregated nuclear proteins, such as pathogenic polyQ proteins, are cleared by a SUMO-dependent quality control pathway, which involves the E3 SUMO ligase PML and the SUMO-targeted ubiquitin ligase RNF4.

Publication types

Comment

MeSH terms

Animals
Humans
Nerve Degeneration / pathology*
Protein Folding*
Proteolysis*