Abstract
The maternal gene bicoid is a key component of the system that determines the pattern of the anterior half of Drosophila embryos. The bicoid protein forms a concentration gradient in early embryos, and is known to bind DNA. Specific binding sites are now shown to confer expression in a region of the embryo that depends on their affinity for bicoid protein: sites of high affinity allow expression further down the bicoid protein gradient than sites of low affinity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Binding Sites
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DNA / metabolism*
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Drosophila / embryology
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Drosophila / genetics*
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Drosophila Proteins
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Gene Expression Regulation*
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Heat-Shock Proteins / genetics
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Homeodomain Proteins*
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Insect Hormones / genetics*
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Promoter Regions, Genetic
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Regulatory Sequences, Nucleic Acid
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Trans-Activators*
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Zygote / metabolism*
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beta-Galactosidase / genetics
Substances
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Drosophila Proteins
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Heat-Shock Proteins
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Homeodomain Proteins
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Insect Hormones
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Trans-Activators
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bcd protein, Drosophila
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DNA
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beta-Galactosidase