TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease

Roberta Sartori; Paul Gregorevic; Marco Sandri

doi:10.1016/j.tem.2014.06.002

TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease

Trends Endocrinol Metab. 2014 Sep;25(9):464-71. doi: 10.1016/j.tem.2014.06.002. Epub 2014 Jul 16.

Authors

Roberta Sartori¹, Paul Gregorevic², Marco Sandri³

Affiliations

¹ Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padova, Italy; Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy.
² Division of Cell Signaling and Metabolism, Baker IDI Heart and Diabetes Institute, Melbourne 3004, Australia.
³ Dulbecco Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padova, Italy; Department of Biomedical Sciences, University of Padova, 35121 Padova, Italy; Telethon Institute of Genetics and Medicine (TIGEM), 80131 Napoli, Italy. Electronic address: marco.sandri@unipd.it.

PMID: 25042839
DOI: 10.1016/j.tem.2014.06.002

Abstract

The transforming growth factor beta (TGFβ) superfamily comprises a large number of secreted proteins that regulate various fundamental biological processes underlying embryonic development and the postnatal regulation of many cell types and organs. Sequence similarities define two ligand subfamilies: the TGFβ/activin subfamily and the bone morphogenetic protein (BMP) subfamily. The discovery that myostatin, a member of the TGFβ/activin subfamily, negatively controls muscle mass attracted attention to this pathway. However, recent findings of a positive role for BMP-mediated signaling in muscle have challenged the model of how the TGFβ network regulates skeletal muscle phenotype. This review illustrates how this complex network integrates crosstalk among members of the TGFβ superfamily and downstream signaling elements to regulate muscle in health and disease.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Activin Receptors / chemistry
Activin Receptors / genetics
Activin Receptors / metabolism
Activins / genetics
Activins / metabolism
Animals
Autophagy
Bone Morphogenetic Protein Receptors / agonists*
Bone Morphogenetic Protein Receptors / genetics
Bone Morphogenetic Protein Receptors / metabolism
Bone Morphogenetic Proteins / metabolism*
Humans
Hypertrophy
Mice, Knockout
Mice, Transgenic
Models, Biological*
Muscle, Skeletal / metabolism*
Muscle, Skeletal / pathology
Muscular Atrophy / metabolism
Muscular Atrophy / pathology
Muscular Diseases / metabolism
Muscular Diseases / pathology
Protein Isoforms / agonists
Protein Isoforms / genetics
Protein Isoforms / metabolism
Receptors, Transforming Growth Factor beta / agonists*
Receptors, Transforming Growth Factor beta / genetics
Receptors, Transforming Growth Factor beta / metabolism
Signal Transduction*
Transforming Growth Factor beta / genetics
Transforming Growth Factor beta / metabolism*

Substances

Bone Morphogenetic Proteins
Protein Isoforms
Receptors, Transforming Growth Factor beta
Transforming Growth Factor beta
Activins
Activin Receptors
Bone Morphogenetic Protein Receptors