Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis

Hamidreza Maroof; Ali Salajegheh; Robert Anthony Smith; Alfred King-Yin Lam

doi:10.1016/j.yexmp.2014.08.002

Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis

Exp Mol Pathol. 2014 Oct;97(2):298-304. doi: 10.1016/j.yexmp.2014.08.002. Epub 2014 Aug 4.

Authors

Hamidreza Maroof¹, Ali Salajegheh¹, Robert Anthony Smith¹, Alfred King-Yin Lam²

Affiliations

¹ Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia.
² Cancer Molecular Pathology, School of Medicine and Griffith Health Institute, Griffith University, Gold Coast, Queensland, Australia. Electronic address: a.lam@griffith.edu.au.

PMID: 25102298
DOI: 10.1016/j.yexmp.2014.08.002

Abstract

MicroRNA-34 is involved in pathogenesis in cancer by targeting different tumor-related genes. It could be a biomarker for predicting the prognosis of patients with cancer. In addition, miR-34 is involved in the tumor angiogenesis. Understanding the mechanism of the miR-34 in cancer and tumor angiogenesis will open horizons for development of anti-cancer and anti-angiogenesis drugs.

Keywords: Angiogenesis; Cancer; miRNA-34.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
MicroRNAs / genetics*
MicroRNAs / metabolism
Neoplasms / genetics*
Neoplasms / metabolism
Neoplasms / physiopathology
Neovascularization, Pathologic / genetics*
Neovascularization, Pathologic / metabolism

Substances

MIRN34 microRNA, human
MicroRNAs