Temporal patterning of neuroblasts controls Notch-mediated cell survival through regulation of Hid or Reaper

Cell. 2014 Aug 28;158(5):1173-1186. doi: 10.1016/j.cell.2014.07.045.

Abstract

Temporal patterning of neural progenitors is one of the core mechanisms generating neuronal diversity in the central nervous system. Here, we show that, in the tips of the outer proliferation center (tOPC) of the developing Drosophila optic lobes, a unique temporal series of transcription factors not only governs the sequential production of distinct neuronal subtypes but also controls the mode of progenitor division, as well as the selective apoptosis of Notch(OFF) or Notch(ON) neurons during binary cell fate decisions. Within a single lineage, intermediate precursors initially do not divide and generate only one neuron; subsequently, precursors divide, but their Notch(ON) progeny systematically die through Reaper activity, whereas later, their Notch(OFF) progeny die through Hid activity. These mechanisms dictate how the tOPC produces neurons for three different optic ganglia. We conclude that temporal patterning generates neuronal diversity by specifying both the identity and survival/death of each unique neuronal subtype.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Cell Survival*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / cytology*
  • Drosophila melanogaster / growth & development
  • Drosophila melanogaster / metabolism
  • Neural Stem Cells
  • Neurogenesis*
  • Neuropeptides / metabolism*
  • Optic Lobe, Nonmammalian / cytology*
  • Optic Lobe, Nonmammalian / metabolism
  • Receptors, Notch / metabolism*

Substances

  • Drosophila Proteins
  • HID protein, Drosophila
  • N protein, Drosophila
  • Neuropeptides
  • Receptors, Notch
  • rpr protein, Drosophila