Abstract
Cilia and flagella are essential organelles in most eukaryotes including human beings. In this review, we will discuss the mode of assembly of these complex organelles that depends on a dynamic process called intraflagellar transport or IFT. IFT delivers structural elements at the distal end of the cilium where assembly takes place, thereby allowing the growth of the organelle. We next discuss the different models for control of cilium length and their alterations in ciliopathies, genetic diseases associated to ciliary defects.
© 2014 médecine/sciences – Inserm.
Publication types
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English Abstract
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Axonemal Dyneins / physiology
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Axoneme / ultrastructure*
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Biological Transport
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Cell Movement
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Chlamydomonas reinhardtii / physiology
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Chlamydomonas reinhardtii / ultrastructure
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Cilia / metabolism
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Cilia / ultrastructure*
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Ciliary Motility Disorders / genetics
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Ciliary Motility Disorders / physiopathology
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Eukaryotic Cells / physiology
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Eukaryotic Cells / ultrastructure*
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Flagella / metabolism
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Flagella / ultrastructure*
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Humans
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Microtubules / physiology
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Microtubules / ultrastructure
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Models, Biological
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Trypanosoma brucei brucei / physiology
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Trypanosoma brucei brucei / ultrastructure
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Tubulin / metabolism