Abstract
Sodium butyrate produces reversible changes in morphology, growth rate, and enzyme activities of several mammalian cell types in culture. Some of these changes are similar to those produced by agents which increase the intracellular level of adenosine 3',5'-cyclic monophosphate (cAMP) or by analogs of cAMP. Sodium butyrate increases the intracellular level of cAMP by about two fold in neuroblastoma cells; therefore, some of the effects of sodium butyrate on these cells may in part be mediated by cAMP. Sodium butyrate appears to have properties of a good chemotherapeutic agent for neuroblastoma tumors because the treatment of neuroblastoma cells in culture causes cell death and "differentiation"; however, it is either innocuous or produces reversible morphological and biochemical alterations in other cell types.
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / metabolism
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Acetylcholinesterase / metabolism
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Adenylate Kinase / metabolism
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Anti-Bacterial Agents / pharmacology
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Bucladesine / pharmacology
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Butyrates / pharmacology*
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Butyrates / therapeutic use
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Caproates / pharmacology
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Cell Differentiation / drug effects
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Cell Division / drug effects*
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Cell Line
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Cell Transformation, Neoplastic
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Cells, Cultured / drug effects*
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Cells, Cultured / ultrastructure
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Cyclic AMP / metabolism
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Cytochalasin B / pharmacology
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DNA / metabolism
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HeLa Cells / drug effects
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Humans
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Neuroblastoma / drug therapy
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Parabens / pharmacology
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Propionates / pharmacology
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Proteins / metabolism
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RNA / metabolism
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Transferases / metabolism
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Tyrosine 3-Monooxygenase / metabolism
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Vinblastine / pharmacology
Substances
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Anti-Bacterial Agents
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Butyrates
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Caproates
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Parabens
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Propionates
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Proteins
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Cytochalasin B
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Vinblastine
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RNA
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Bucladesine
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DNA
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Cyclic AMP
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Tyrosine 3-Monooxygenase
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Transferases
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Adenylate Kinase
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Acetylcholinesterase
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3',5'-Cyclic-AMP Phosphodiesterases