Global resource distribution: allocation of actin building blocks by profilin

Dev Cell. 2015 Jan 12;32(1):5-6. doi: 10.1016/j.devcel.2014.12.022.

Abstract

How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembled by Arp2/3 complex and formins or Ena/VASP.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Actin Cytoskeleton / metabolism*
  • Actin-Related Protein 2-3 Complex / metabolism*
  • Actins / metabolism*
  • Animals
  • Female
  • Homeostasis / physiology*
  • Male
  • Profilins / metabolism*
  • Schizosaccharomyces / metabolism*
  • Schizosaccharomyces pombe Proteins / metabolism*

Substances

  • Actin-Related Protein 2-3 Complex
  • Actins
  • Profilins
  • Schizosaccharomyces pombe Proteins