Abstract
How cells regulate the distribution of a limited pool of actin between two competing structures has long been a mystery. Complementary studies from Suarez et al. (2015) and Rotty et al. (2015) now show that profilin controls the partitioning of actin monomers between competing actin networks assembled by Arp2/3 complex and formins or Ena/VASP.
Copyright © 2015 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Comment
MeSH terms
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Actin Cytoskeleton / metabolism*
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Actin-Related Protein 2-3 Complex / metabolism*
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Actins / metabolism*
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Animals
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Female
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Homeostasis / physiology*
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Male
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Profilins / metabolism*
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Schizosaccharomyces / metabolism*
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Schizosaccharomyces pombe Proteins / metabolism*
Substances
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Actin-Related Protein 2-3 Complex
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Actins
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Profilins
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Schizosaccharomyces pombe Proteins