Abstract
RUNX proteins belong to a family of metazoan transcription factors that serve as master regulators of development. They are frequently deregulated in human cancers, indicating a prominent and, at times, paradoxical role in cancer pathogenesis. The contextual cues that direct RUNX function represent a fast-growing field in cancer research and could provide insights that are applicable to early cancer detection and treatment. This Review describes how RUNX proteins communicate with key signalling pathways during the multistep progression to malignancy; in particular, we highlight the emerging partnership of RUNX with p53 in cancer suppression.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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ADP-Ribosylation Factors / metabolism
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Cell Differentiation / genetics
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Cell Proliferation / genetics
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Core Binding Factor alpha Subunits / genetics*
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Core Binding Factor alpha Subunits / immunology
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Core Binding Factor alpha Subunits / metabolism
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Cyclin-Dependent Kinases / metabolism
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DNA Damage / genetics
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DNA Methylation
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DNA Repair / genetics
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Humans
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Inflammation / immunology
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Neoplasms / genetics*
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Phosphorylation
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Signal Transduction / genetics
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Transcription, Genetic / genetics
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Tumor Suppressor Protein p53 / metabolism*
Substances
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Core Binding Factor alpha Subunits
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Tumor Suppressor Protein p53
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Cyclin-Dependent Kinases
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ADP-Ribosylation Factors