A novel bipartite centrosome coordinates the apicomplexan cell cycle

PLoS Biol. 2015 Mar 3;13(3):e1002093. doi: 10.1371/journal.pbio.1002093. eCollection 2015 Mar.

Abstract

Apicomplexan parasites can change fundamental features of cell division during their life cycles, suspending cytokinesis when needed and changing proliferative scale in different hosts and tissues. The structural and molecular basis for this remarkable cell cycle flexibility is not fully understood, although the centrosome serves a key role in determining when and how much replication will occur. Here we describe the discovery of multiple replicating core complexes with distinct protein composition and function in the centrosome of Toxoplasma gondii. An outer core complex distal from the nucleus contains the TgCentrin1/TgSfi1 protein pair, along with the cartwheel protein TgSas-6 and a novel Aurora-related kinase, while an inner core closely aligned with the unique spindle pole (centrocone) holds distant orthologs of the CEP250/C-Nap protein family. This outer/inner spatial relationship of centrosome cores is maintained throughout the cell cycle. When in metaphase, the duplicated cores align to opposite sides of the kinetochores in a linear array. As parasites transition into S phase, the cores sequentially duplicate, outer core first and inner core second, ensuring that each daughter parasite inherits one copy of each type of centrosome core. A key serine/threonine kinase distantly related to the MAPK family is localized to the centrosome, where it restricts core duplication to once per cycle and ensures the proper formation of new daughter parasites. Genetic analysis of the outer core in a temperature-sensitive mutant demonstrated this core functions primarily in cytokinesis. An inhibition of ts-TgSfi1 function at high temperature caused the loss of outer cores and a severe block to budding, while at the same time the inner core amplified along with the unique spindle pole, indicating the inner core and spindle pole are independent and co-regulated. The discovery of a novel bipartite organization in the parasite centrosome that segregates the functions of karyokinesis and cytokinesis provides an explanation for how cell cycle flexibility is achieved in apicomplexan life cycles.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Aurora Kinases / genetics
  • Aurora Kinases / metabolism
  • Cell Cycle Proteins / genetics*
  • Cell Cycle Proteins / metabolism
  • Cell Nucleus / metabolism
  • Cell Nucleus / ultrastructure
  • Cell Nucleus Division*
  • Centrosome / metabolism*
  • Centrosome / ultrastructure
  • Culture Media
  • Cytokinesis*
  • Fibroblasts / parasitology
  • Fibroblasts / pathology
  • Gene Expression Regulation
  • Humans
  • Kinetochores / metabolism
  • Kinetochores / ultrastructure
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism
  • Primary Cell Culture
  • Protozoan Proteins / genetics*
  • Protozoan Proteins / metabolism
  • Signal Transduction
  • Temperature
  • Toxoplasma / genetics*
  • Toxoplasma / metabolism
  • Toxoplasma / ultrastructure

Substances

  • Cell Cycle Proteins
  • Culture Media
  • Protozoan Proteins
  • Aurora Kinases
  • Mitogen-Activated Protein Kinases