Metabolic switches linked to pluripotency and embryonic stem cell differentiation

Ng Shyh-Chang; George Q Daley

doi:10.1016/j.cmet.2015.02.011

Metabolic switches linked to pluripotency and embryonic stem cell differentiation

Cell Metab. 2015 Mar 3;21(3):349-50. doi: 10.1016/j.cmet.2015.02.011.

Authors

Ng Shyh-Chang¹, George Q Daley²

Affiliations

¹ Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore.
² Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Harvard Stem Cell Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Manton Center for Orphan Disease Research, Boston, MA 02115, USA; Howard Hughes Medical Institute, Boston, MA 02115, USA. Electronic address: george.daley@childrens.harvard.edu.

PMID: 25738450
DOI: 10.1016/j.cmet.2015.02.011

Abstract

Embryonic stem cells (ESCs) manifest a unique metabolism that is intimately linked to their pluripotent state. In this issue, Moussaieff et al. (2015) find that ESCs utilize glycolysis to fuel high rates of cytosolic acetyl-CoA synthesis to maintain the histone acetylation required for pluripotency.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Acetyl Coenzyme A / metabolism*
Animals
Cell Differentiation / physiology*
Embryonic Stem Cells / metabolism*
Embryonic Stem Cells / physiology*
Glycolysis / physiology*
Histones / metabolism*
Humans

Substances

Histones
Acetyl Coenzyme A

Grants and funding

Howard Hughes Medical Institute/United States