A broken krebs cycle in macrophages

Luke A J O'Neill

doi:10.1016/j.immuni.2015.02.017

A broken krebs cycle in macrophages

Immunity. 2015 Mar 17;42(3):393-4. doi: 10.1016/j.immuni.2015.02.017.

Author

Luke A J O'Neill¹

Affiliation

¹ School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland. Electronic address: laoneill@tcd.ie.

PMID: 25786167
DOI: 10.1016/j.immuni.2015.02.017

Abstract

Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a systems approach for unbiased analysis of cellular metabolism that reveals key metabolites and metabolic pathways required for distinct macrophage polarization states.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Gene Regulatory Networks / immunology*
Immunity, Innate*
Macrophages / metabolism*
Mitochondria / metabolism*
Transcription, Genetic / immunology*