Cerebellar damage impairs internal predictions for sensory and motor function

Amanda S Therrien; Amy J Bastian

doi:10.1016/j.conb.2015.03.013

Cerebellar damage impairs internal predictions for sensory and motor function

Curr Opin Neurobiol. 2015 Aug:33:127-33. doi: 10.1016/j.conb.2015.03.013. Epub 2015 Apr 6.

Authors

Amanda S Therrien¹, Amy J Bastian²

Affiliations

¹ Kennedy Krieger Institute, Baltimore, MD, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States.
² Kennedy Krieger Institute, Baltimore, MD, United States; Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, United States. Electronic address: bastian@kennedykrieger.org.

Abstract

The cerebellum is connected to cerebral areas that subserve a range of sensory and motor functions. In this review, we summarize new literature demonstrating deficits in visual perception, proprioception, motor control, and motor learning performance following cerebellar damage. In particular, we highlight novel results that together suggest a general role of the cerebellum in estimating and predicting movement dynamics of the body and environmental stimuli. These findings agree with the hypothesized role of the cerebellum in the generation and calibration of predictive models for a variety of functions.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Animals
Cerebellar Diseases / complications*
Cerebellum / physiology
Humans
Movement Disorders / etiology*
Perception / physiology*
Sensation Disorders / etiology*

Grants and funding

R01 HD040289/HD/NICHD NIH HHS/United States