Memory-Associated Dynamic Regulation of the "Stable" Core of the Chromatin Particle

Iva B Zovkic; J David Sweatt

doi:10.1016/j.neuron.2015.06.025

Memory-Associated Dynamic Regulation of the "Stable" Core of the Chromatin Particle

Neuron. 2015 Jul 1;87(1):1-4. doi: 10.1016/j.neuron.2015.06.025.

Authors

Iva B Zovkic¹, J David Sweatt²

Affiliations

¹ Department of Psychology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada. Electronic address: iva.zovkic@utoronto.ca.
² Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294-2182, USA. Electronic address: dsweatt@uab.edu.

Abstract

Chromatin is a critical regulator of neural plasticity, but basic principles of chromatin function in neurons are unclear. In this issue of Neuron, Maze et al. (2015) establish histone H3.3 turnover as a novel mechanism contributing to CNS gene regulation, synaptic plasticity, and cognition.

Publication types

Comment

MeSH terms

Animals
Brain / metabolism*
Chromatin / metabolism*
Female
Gene Expression Regulation, Developmental*
Histones / metabolism*
Humans
Male
Neuronal Plasticity / genetics*
Neurons / metabolism*
Nucleosomes / metabolism*

Substances

Chromatin
Histones
Nucleosomes

Grants and funding

R01 MH057014/MH/NIMH NIH HHS/United States