Liver X receptors at the intersection of lipid metabolism and atherogenesis

Atherosclerosis. 2015 Sep;242(1):29-36. doi: 10.1016/j.atherosclerosis.2015.06.042. Epub 2015 Jul 2.

Authors

Stephen D Lee¹, Peter Tontonoz²

Affiliations

¹ Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA.
² Howard Hughes Medical Institute, Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA. Electronic address: ptontonoz@mednet.ucla.edu.

PMID: 26164157
PMCID: PMC4546914
DOI: 10.1016/j.atherosclerosis.2015.06.042

No abstract available

Keywords: Atherosclerosis; LXR; Lipid metabolism; Nuclear receptor.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

ATP Binding Cassette Transporter 1 / metabolism
Animals
Apoptosis
Atherosclerosis / metabolism*
Atherosclerosis / pathology
Biological Transport
Cholesterol / metabolism
Disease Progression
Endothelium, Vascular / metabolism
Endothelium, Vascular / pathology
Enterocytes / metabolism
Hepatocytes / metabolism
Homeostasis
Humans
Hypercholesterolemia / complications
Hypercholesterolemia / metabolism
Inflammation
Intestine, Small / metabolism
Lipid Metabolism*
Lipoproteins / metabolism
Liver X Receptors
Macrophages / metabolism
Molecular Targeted Therapy
Orphan Nuclear Receptors / agonists
Orphan Nuclear Receptors / physiology*
Signal Transduction

Substances

ATP Binding Cassette Transporter 1
Lipoproteins
Liver X Receptors
Orphan Nuclear Receptors
Cholesterol

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