A Phosphoinositide Code for Primary Cilia

Dev Cell. 2015 Aug 24;34(4):379-80. doi: 10.1016/j.devcel.2015.08.008.

Abstract

How phosphoinositide metabolism is coupled to primary cilia physiology is poorly understood. Reporting recently in Developmental Cell, Chávez et al. (2015) and Garcia-Gonzalo et al. (2015) show that INPP5E-mediated phosphoinositide metabolism, which creates a specific phosphoinositide distribution, ensures proper protein trafficking and Hh signaling in primary cilia.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cilia / metabolism*
  • Hedgehog Proteins / metabolism*
  • Phosphatidylinositol Phosphates / metabolism*
  • Phosphoric Monoester Hydrolases / genetics*
  • Proteins / metabolism*
  • Receptors, G-Protein-Coupled / metabolism*

Substances

  • Hedgehog Proteins
  • Phosphatidylinositol Phosphates
  • Proteins
  • Receptors, G-Protein-Coupled
  • Phosphoric Monoester Hydrolases