No driver behind the wheel? Targeting transcription in cancer

Hector L Franco; W Lee Kraus

doi:10.1016/j.cell.2015.09.013

No driver behind the wheel? Targeting transcription in cancer

Cell. 2015 Sep 24;163(1):28-30. doi: 10.1016/j.cell.2015.09.013.

Authors

Hector L Franco¹, W Lee Kraus²

Affiliations

¹ Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
² Laboratory of Signaling and Gene Regulation, Cecil H. and Ida Green Center for Reproductive Biology Sciences and Division of Basic Reproductive Biology Research, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: lee.kraus@utsouthwestern.edu.

PMID: 26406367
DOI: 10.1016/j.cell.2015.09.013

Abstract

Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

Publication types

Comment

MeSH terms

Animals
Cyclin-Dependent Kinases / metabolism*
Gene Expression Regulation, Neoplastic*
Humans
Transcription, Genetic*
Triple Negative Breast Neoplasms / genetics*

Substances

Cyclin-Dependent Kinases