Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

Ross D Feldman; Lee E Limbird

doi:10.1016/j.tem.2015.09.002

Copernicus Revisited: Overturning Ptolemy's View of the GPER Universe

Trends Endocrinol Metab. 2015 Nov;26(11):592-594. doi: 10.1016/j.tem.2015.09.002. Epub 2015 Oct 16.

Authors

Ross D Feldman¹, Lee E Limbird²

Affiliations

¹ Discipline of Medicine, Memorial University of Newfoundland, St John's, Canada. Electronic address: ross.feldman@med.mun.ca.
² Department of Life and Physical Sciences, Fisk University, Nashville, TN, USA.

PMID: 26482875
DOI: 10.1016/j.tem.2015.09.002

Abstract

Whether aldosterone activates the G-protein-coupled estrogen receptor (GPER) has been questioned, recently, in the name of Copernicus. However, for G-protein-coupled receptors (GPCRs) multiple hormone activators are common. Further, studies in mineralocorticoid receptor (MR)-deficient systems, with pharmacological GPER-selective antagonists or regulation of GPER expression, consistently show that some aldosterone effects can be GPER mediated.

Keywords: GPCR; GPER; aldosterone; estrogen.

Publication types

Review

MeSH terms

Aldosterone / metabolism*
Humans
Receptors, Estrogen / metabolism*
Receptors, G-Protein-Coupled / metabolism*

Substances

GPER1 protein, human
Receptors, Estrogen
Receptors, G-Protein-Coupled
Aldosterone