The Cpf1 CRISPR-Cas protein expands genome-editing tools

Robert D Fagerlund; Raymond H J Staals; Peter C Fineran

doi:10.1186/s13059-015-0824-9

The Cpf1 CRISPR-Cas protein expands genome-editing tools

Genome Biol. 2015 Nov 17:16:251. doi: 10.1186/s13059-015-0824-9.

Authors

Robert D Fagerlund¹, Raymond H J Staals¹, Peter C Fineran²

Affiliations

¹ Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, 9054, New Zealand.
² Department of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin, 9054, New Zealand. peter.fineran@otago.ac.nz.

Abstract

CRISPR-Cas systems have immense biotechnological utility. A recent study reveals the potential of the Cpf1 nuclease to complement and extend the existing CRISPR-Cas9 genome-editing tools.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacterial Proteins / genetics*
Bacteriophages / genetics*
CRISPR-Cas Systems / genetics*
Endodeoxyribonucleases / genetics*
Escherichia coli / genetics
Francisella / genetics
Genetic Engineering
Genome, Human*
Humans
Mutation
RNA Editing / genetics*

Substances

Bacterial Proteins
Endodeoxyribonucleases