Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices

Nat Cell Biol. 2016 Jan;18(1):33-42. doi: 10.1038/ncb3277. Epub 2015 Nov 30.

Abstract

Cells test the rigidity of the extracellular matrix by applying forces to it through integrin adhesions. Recent measurements show that these forces are applied by local micrometre-scale contractions, but how contraction force is regulated by rigidity is unknown. Here we performed high temporal- and spatial-resolution tracking of contractile forces by plating cells on sub-micrometre elastomeric pillars. We found that actomyosin-based sarcomere-like contractile units (CUs) simultaneously moved opposing pillars in net steps of ∼2.5 nm, independent of rigidity. What correlated with rigidity was the number of steps taken to reach a force level that activated recruitment of α-actinin to the CUs. When we removed actomyosin restriction by depleting tropomyosin 2.1, we observed larger steps and higher forces that resulted in aberrant rigidity sensing and growth of non-transformed cells on soft matrices. Thus, we conclude that tropomyosin 2.1 acts as a suppressor of growth on soft matrices by supporting proper rigidity sensing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actin Cytoskeleton
  • Actins / metabolism
  • Actomyosin / metabolism*
  • Cell Adhesion
  • Extracellular Matrix / metabolism*
  • Humans
  • Muscle Contraction / physiology*
  • Sarcomeres / metabolism*
  • Stress, Mechanical*
  • Tropomyosin / metabolism*

Substances

  • Actins
  • TPM2 protein, human
  • Tropomyosin
  • Actomyosin