Hidden in the mist no more: physical force in cell biology

Nat Methods. 2016 Feb;13(2):124-5. doi: 10.1038/nmeth.3744.

Abstract

To drive its migration through a fibrillar matrix—and thus to spread, invade or metastasize—a cancer cell must exert physical forces. The first visualization of these forces in three dimensions reveals surprising migration dynamics.

Publication types

  • News
  • Comment

MeSH terms

  • Biopolymers / chemistry*
  • Breast Neoplasms*
  • Female
  • Humans
  • Imaging, Three-Dimensional / instrumentation*
  • Imaging, Three-Dimensional / methods*
  • Microscopy, Atomic Force / instrumentation*
  • Microscopy, Atomic Force / methods*

Substances

  • Biopolymers