Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events

Shantanu P Jadhav; Gideon Rothschild; Demetris K Roumis; Loren M Frank

doi:10.1016/j.neuron.2016.02.010

Coordinated Excitation and Inhibition of Prefrontal Ensembles during Awake Hippocampal Sharp-Wave Ripple Events

Neuron. 2016 Apr 6;90(1):113-27. doi: 10.1016/j.neuron.2016.02.010. Epub 2016 Mar 10.

Authors

Shantanu P Jadhav¹, Gideon Rothschild², Demetris K Roumis², Loren M Frank³

Affiliations

¹ Department of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94117, USA. Electronic address: shantanu@brandeis.edu.
² Department of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94117, USA.
³ Department of Physiology and Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94117, USA; Howard Hughes Medical Institute. Electronic address: loren@phy.ucsf.edu.

Abstract

Interactions between the hippocampus and prefrontal cortex (PFC) are critical for learning and memory. Hippocampal activity during awake sharp-wave ripple (SWR) events is important for spatial learning, and hippocampal SWR activity often represents past or potential future experiences. Whether or how this reactivation engages the PFC, and how reactivation might interact with ongoing patterns of PFC activity, remains unclear. We recorded hippocampal CA1 and PFC activity in animals learning spatial tasks and found that many PFC cells showed spiking modulation during SWRs. Unlike in CA1, SWR-related activity in PFC comprised both excitation and inhibition of distinct populations. Within individual SWRs, excitation activated PFC cells with representations related to the concurrently reactivated hippocampal representation, while inhibition suppressed PFC cells with unrelated representations. Thus, awake SWRs mark times of strong coordination between hippocampus and PFC that reflects structured reactivation of representations related to ongoing experience.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Brain Waves / physiology*
CA1 Region, Hippocampal / physiology*
Electroencephalography
Hippocampus / physiology
Neural Inhibition
Neurons / physiology*
Prefrontal Cortex / physiology*
Rats
Rats, Long-Evans
Spatial Learning / physiology*
Wakefulness / physiology*

Abstract

Publication types

MeSH terms

Grants and funding