Types of Ubiquitin Ligases

Francesca Ester Morreale; Helen Walden

doi:10.1016/j.cell.2016.03.003

Types of Ubiquitin Ligases

Cell. 2016 Mar 24;165(1):248-248.e1. doi: 10.1016/j.cell.2016.03.003.

Authors

Francesca Ester Morreale¹, Helen Walden¹

Affiliation

¹ MRC Protein Phosphorylation and Ubiquitylation Unit at University of Dundee, Scotland DD1 5EH, UK.

PMID: 27015313
DOI: 10.1016/j.cell.2016.03.003

Abstract

Ubiquitination is a post-translational modification of proteins involved in a variety of cellular processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases). This SnapShot highlights the main types of E3 ubiquitin ligases, which can be classified in three families depending on the presence of characteristic domains and on the mechanism of ubiquitin transfer to the substrate protein.

MeSH terms

Animals
Humans
Protein Processing, Post-Translational
Proteins / metabolism
Ubiquitin-Conjugating Enzymes / chemistry*
Ubiquitin-Conjugating Enzymes / metabolism*
Ubiquitination

Substances

Proteins
Ubiquitin-Conjugating Enzymes

Grants and funding

MC_UU_12016/12/MRC_/Medical Research Council/United Kingdom