Abstract
Inositol 1,4,5-trisphosphate receptors (IP3Rs) and ryanodine receptors are the channels responsible for Ca(2+)release from the endoplasmic and sarcoplasmic reticulum. Research inScience Signalingby Alzayadyet al show that all four IP3-binding sites within the tetrameric IP3R must bind IP3before the channel can open, which has important consequences for the distribution of both IP3and IP3R activity within cells.
Copyright © 2016, American Association for the Advancement of Science.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Calcium / metabolism*
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Calcium Signaling
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Humans
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Inositol 1,4,5-Trisphosphate / chemistry*
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Inositol 1,4,5-Trisphosphate / metabolism
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Inositol 1,4,5-Trisphosphate Receptors / chemistry*
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Inositol 1,4,5-Trisphosphate Receptors / metabolism
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Ion Channel Gating*
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Models, Molecular
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Molecular Structure
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Protein Binding
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Protein Domains
Substances
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Inositol 1,4,5-Trisphosphate Receptors
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Inositol 1,4,5-Trisphosphate
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Calcium