From Mosquitos to Humans: Genetic Evolution of Zika Virus

Cell Host Microbe. 2016 May 11;19(5):561-5. doi: 10.1016/j.chom.2016.04.006. Epub 2016 Apr 15.

Abstract

Initially isolated in 1947, Zika virus (ZIKV) has recently emerged as a significant public health concern. Sequence analysis of all 41 known ZIKV RNA open reading frames to date indicates that ZIKV has undergone significant changes in both protein and nucleotide sequences during the past half century.

MeSH terms

  • Africa / epidemiology
  • Amino Acid Substitution
  • Animals
  • Asia / epidemiology
  • Culicidae / virology*
  • Evolution, Molecular
  • Genetic Variation
  • Humans
  • Molecular Epidemiology
  • Phylogeography
  • Sequence Analysis
  • Viral Envelope Proteins / genetics
  • Viral Proteins / genetics
  • Zika Virus / genetics*
  • Zika Virus / isolation & purification
  • Zika Virus Infection / epidemiology
  • Zika Virus Infection / virology*

Substances

  • Viral Envelope Proteins
  • Viral Proteins
  • prM protein, Flavivirus