Metformin as a Tool to Target Aging

Cell Metab. 2016 Jun 14;23(6):1060-1065. doi: 10.1016/j.cmet.2016.05.011.

Abstract

Aging has been targeted by genetic and dietary manipulation and by drugs in order to increase lifespan and health span in numerous models. Metformin, which has demonstrated protective effects against several age-related diseases in humans, will be tested in the TAME (Targeting Aging with Metformin) trial, as the initial step in the development of increasingly effective next-generation drugs.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural

MeSH terms

  • Aging / drug effects*
  • Aging / physiology*
  • Animals
  • Clinical Trials as Topic
  • Humans
  • Longevity / drug effects
  • Metformin / pharmacology*
  • Models, Animal
  • Models, Biological

Substances

  • Metformin