Linking Long Noncoding RNA Localization and Function

Ling-Ling Chen

doi:10.1016/j.tibs.2016.07.003

Linking Long Noncoding RNA Localization and Function

Trends Biochem Sci. 2016 Sep;41(9):761-772. doi: 10.1016/j.tibs.2016.07.003. Epub 2016 Aug 4.

Author

Ling-Ling Chen¹

Affiliation

¹ State Key Laboratory of Molecular Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; School of Life Science and Technology, Shanghai Tech University, 100 Haike Road, Shanghai, China. Electronic address: linglingchen@sibcb.ac.cn.

PMID: 27499234
DOI: 10.1016/j.tibs.2016.07.003

Abstract

Recent studies have revealed the regulatory potential of many long noncoding RNAs (lncRNAs). Most lncRNAs, like mRNAs, are transcribed by RNA polymerase II and are capped, polyadenylated, and spliced. However, the subcellular fates of lncRNAs are distinct and the mechanisms of action are diverse. Investigating the mechanisms that determine the subcellular fate of lncRNAs has the potential to provide new insights into their biogenesis and specialized functions.

Keywords: long noncoding RNA biogenesis; long noncoding RNAs; nuclear retention; subcellular localization.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
RNA Transport*
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism*

Substances

RNA, Long Noncoding