Abstract
Direct electron detectors have played a key role in the recent increase in the power of single-particle electron cryomicroscopy (cryoEM). In this chapter, we summarize the background to these recent developments, give a practical guide to their optimal use, and discuss future directions.
Keywords:
CMOS; DDD; DQE; Direct Electron; Electron microscopy; FEI; Gatan; MTF; Sensor; cryoEM.
© 2016 Elsevier Inc. All rights reserved.
Publication types
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Historical Article
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Review
MeSH terms
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Bacterial Proteins / ultrastructure
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Biosensing Techniques / history
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Biosensing Techniques / instrumentation
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Biosensing Techniques / methods*
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Cryoelectron Microscopy / history
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Cryoelectron Microscopy / instrumentation
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Cryoelectron Microscopy / methods*
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Electrons*
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Escherichia coli / chemistry
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Escherichia coli / enzymology
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History, 20th Century
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History, 21st Century
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Monte Carlo Method
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Silicon / chemistry
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Software*
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beta-Galactosidase / ultrastructure
Substances
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Bacterial Proteins
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beta-Galactosidase
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Silicon