Subthalamic oscillations and phase amplitude coupling are greater in the more affected hemisphere in Parkinson's disease

Lauren A Shreve; Anca Velisar; Mahsa Malekmohammadi; Mandy Miller Koop; Megan Trager; Emma J Quinn; Bruce C Hill; Zack Blumenfeld; Camilla Kilbane; Alessandra Mantovani; Jaimie M Henderson; Helen Brontë-Stewart

doi:10.1016/j.clinph.2016.10.095

Subthalamic oscillations and phase amplitude coupling are greater in the more affected hemisphere in Parkinson's disease

Clin Neurophysiol. 2017 Jan;128(1):128-137. doi: 10.1016/j.clinph.2016.10.095. Epub 2016 Nov 10.

Affiliations

¹ Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
² Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA.
³ Department of Neurosurgery, Stanford University, Stanford, CA, USA.
⁴ Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA; Department of Neurosurgery, Stanford University, Stanford, CA, USA. Electronic address: hbs@stanford.edu.

PMID: 27889627
DOI: 10.1016/j.clinph.2016.10.095

Abstract

Objective: Determine the incidence of resting state oscillations in alpha/beta, high frequency (HFO) bands, and their phase amplitude coupling (PAC) in a large cohort in Parkinson's disease (PD).

Methods: Intra-operative local field potentials (LFPs) from subthalamic nucleus (STN) were recorded from 100 PD subjects, data from 74 subjects were included in the analysis.

Results: Alpha/beta oscillations were evident in >99%, HFO in 87% and PAC in 98% of cases. Alpha/beta oscillations (P<0.01) and PAC were stronger in the more affected (MA) hemisphere (P=0.03). Alpha/beta oscillations were primarily found in 13-20Hz (low beta). Beta and HFO frequencies with the greatest coupling, were positively correlated (P=0.001). Tremor attenuated alpha (P=0.002) and beta band oscillations (P<0.001).

Conclusions: STN alpha/beta band oscillations and PAC were evident in ⩾98% cases and were greater in MA hemisphere. Resting tremor attenuated underlying alpha/beta band oscillations.

Significance: Beta band LFP power may be used to drive adaptive deep brain stimulation (aDBS), augmented by a kinematic classifier in tremor dominant PD.

Keywords: Beta oscillations; Deep brain stimulation; Parkinson’s disease; Phase amplitude coupling; Phenotypes; Tremor.

MeSH terms

Aged
Alpha Rhythm* / physiology
Beta Rhythm* / physiology
Cohort Studies
Deep Brain Stimulation / methods*
Female
Humans
Male
Middle Aged
Parkinson Disease / diagnosis
Parkinson Disease / physiopathology*
Parkinson Disease / surgery
Subthalamic Nucleus / physiopathology*
Subthalamic Nucleus / surgery

Grants and funding

R21 NS096398/NS/NINDS NIH HHS/United States