Resistant starch suppresses postprandial hypertriglyceridemia in rats

Hiroko Matsuda; Kodai Kumazaki; Ryo Otokozawa; Mamiko Tanaka; Eri Udagawa; Takaaki Shirai

doi:10.1016/j.foodres.2016.10.022

Resistant starch suppresses postprandial hypertriglyceridemia in rats

Food Res Int. 2016 Nov;89(Pt 1):838-842. doi: 10.1016/j.foodres.2016.10.022. Epub 2016 Oct 15.

Authors

Hiroko Matsuda¹, Kodai Kumazaki², Ryo Otokozawa³, Mamiko Tanaka⁴, Eri Udagawa⁵, Takaaki Shirai⁶

Affiliations

¹ Laboratory of Salad Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan. Electronic address: hmatsu1@kaiyodai.ac.jp.
² Laboratory of Salad Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan. Electronic address: kuma89758@gmail.com.
³ Laboratory of Salad Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan. Electronic address: ryo920607@gmail.com.
⁴ Laboratory of Salad Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan. Electronic address: mubbc7@gmail.com.
⁵ Laboratory of Salad Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan.
⁶ Laboratory of Salad Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Tokyo 108-8477, Japan. Electronic address: tshirai@kaiyodai.ac.jp.

PMID: 28460986
DOI: 10.1016/j.foodres.2016.10.022

Abstract

Postprandial increase in blood triglyceride levels is an independent risk factor for coronary artery disease, and dietary resistant starch (RS) is increasingly being considered for its contribution to disease prevention. Specifically, RS has beneficial effects on of the glycemic index, diabetes, cholesterol levels, and weight management. However, the effects of once-daily intake of RS on postprandial hypertriglyceridemia remain poorly characterized. In this study, the effects of a single administration of cornstarch-derived RS on postprandial increases in blood triglyceride levels were investigated in rats using oral fat tolerance/loading tests. Following the administration of lipid meals, increases in serum triglycerides levels were significantly reduced in rats fed corn oil containing 500mg/mL RS. Moreover, fecal lipid volumes and wet weights following lipid meals were significantly greater in rats fed corn oil containing 500mg/mL RS than in the corn oil only group, confirming the inhibition of dietary fat absorption. Finally, a significant positive correlation was observed between fecal lipid contents and wet weights in rats administered RS. These results suggest that RS intake with dietary fats induces defecation and confirm results of recent reports on the health-promoting potential of once-daily RS intake.

Keywords: Chenodeoxycholic acid (PubChem CID: 10133); Cholic acid (PubChem CID: 221493); Citric acid (PubChem CID: 311); Deoxycholic acid (PubChem CID: 222528); Ethanol (PubChem CID: 702); Lipase (PubChem CID: 54603431); Oral fat tolerance/loading test; Postprandial hypertriglyceridemia; Resistant starch; Taurocholic acid (PubChem CID: 6675).