Insights into Stearoyl-CoA Desaturase-1 Regulation of Systemic Metabolism

Trends Endocrinol Metab. 2017 Dec;28(12):831-842. doi: 10.1016/j.tem.2017.10.003. Epub 2017 Oct 28.

Abstract

Stearoyl-coenzyme A desaturase 1 (SCD1) is a central regulator of fuel metabolism and may represent a therapeutic target to control obesity and the progression of related metabolic diseases including type 2 diabetes and hepatic steatosis. SCD1 catalyzes the synthesis of monounsaturated fatty acids (MUFAs), mainly oleate and palmitoleate, which are important in controlling weight gain in response to feeding high carbohydrate diets. In this review, we evaluate the role of SCD1 isoform in the regulation of lipid and glucose metabolism in metabolic tissues. These highlights of recent findings are aimed toward advancing our understanding of the role of SCD1 in the development of metabolic diseases, which may help evaluate the possible health outcomes of modulating MUFA levels through targeting SCD1 activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Fatty Acids / metabolism
  • Glucose / metabolism
  • Humans
  • Metabolic Diseases / enzymology*
  • Metabolic Diseases / metabolism*
  • Protein Isoforms / metabolism
  • Stearoyl-CoA Desaturase / metabolism*

Substances

  • Fatty Acids
  • Protein Isoforms
  • Stearoyl-CoA Desaturase
  • Glucose