Peripheral and Central Mechanisms of Itch

Neuron. 2018 May 2;98(3):482-494. doi: 10.1016/j.neuron.2018.03.023.

Abstract

Itch is a unique sensory experience that is encoded by genetically distinguishable neurons both in the peripheral nervous system (PNS) and central nervous system (CNS) to elicit a characteristic behavioral response (scratching). Itch interacts with the other sensory modalities at multiple locations, from its initiation in a particular dermatome to its transmission to the brain where it is finally perceived. In this review, we summarize the current understanding of the molecular and neural mechanisms of itch by starting in the periphery, where itch is initiated, and discussing the circuits involved in itch processing in the CNS.

Keywords: G protein-coupled receptors; TRP channels; cytokines; dorsal root ganglia; itch; mast cells; neuroimmunology; pain; sensory neuron; spinal cord.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Central Nervous System / metabolism
  • Central Nervous System / pathology
  • Central Nervous System / physiopathology
  • Humans
  • Peripheral Nervous System / metabolism
  • Peripheral Nervous System / physiopathology*
  • Pruritus / genetics
  • Pruritus / metabolism
  • Pruritus / physiopathology*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism
  • Sensory Receptor Cells / physiology*
  • Skin / metabolism
  • Skin / pathology
  • Skin / physiopathology*
  • Spinal Cord / metabolism
  • Spinal Cord / physiopathology*

Substances

  • Receptors, G-Protein-Coupled