Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

Ying Yang; Phillip J Hsu; Yu-Sheng Chen; Yun-Gui Yang

doi:10.1038/s41422-018-0040-8

Dynamic transcriptomic m⁶A decoration: writers, erasers, readers and functions in RNA metabolism

Cell Res. 2018 Jun;28(6):616-624. doi: 10.1038/s41422-018-0040-8. Epub 2018 May 22.

Authors

Ying Yang^{1

2

3}, Phillip J Hsu^{4

5}, Yu-Sheng Chen^{1

2}, Yun-Gui Yang^{6

7

8}

Affiliations

¹ CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.
⁴ Department of Chemistry and Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago, Chicago, IL, 60637, USA.
⁵ Medical Scientist Training Program/Committee on Immunology, The University of Chicago, Chicago, IL, 60637, USA.
⁶ CAS Key Laboratory of Genomic and Precision Medicine, Collaborative Innovation Center of Genetics and Development, College of Future Technology, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China. ygyang@big.ac.cn.
⁷ University of Chinese Academy of Sciences, Beijing, 100049, China. ygyang@big.ac.cn.
⁸ Institute of Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China. ygyang@big.ac.cn.

Abstract

N⁶-methyladenosine (m⁶A) is a chemical modification present in multiple RNA species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze, recognize, and remove m⁶A have revealed its comprehensive roles in almost every aspect of mRNA metabolism, as well as in a variety of physiological processes. This review describes the current understanding of the m⁶A modification, particularly the functions of its writers, erasers, readers in RNA metabolism, with an emphasis on its role in regulating the isoform dosage of mRNAs.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adenosine / analogs & derivatives*
Adenosine / genetics
Adenosine / metabolism
Alpha-Ketoglutarate-Dependent Dioxygenase FTO / metabolism
Animals
Humans
Methyltransferases / metabolism
RNA / genetics
RNA / metabolism*
RNA Isoforms / genetics
RNA Isoforms / metabolism
RNA, Messenger / genetics
RNA, Messenger / metabolism
RNA-Binding Proteins / metabolism
Transcriptome*

Substances

RNA Isoforms
RNA, Messenger
RNA-Binding Proteins
RNA
N-methyladenosine
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Methyltransferases
Adenosine

Abstract

Publication types

MeSH terms

Substances

Grants and funding