Abstract
The emergence of form and function during mammalian embryogenesis is a complex process that involves multiple regulatory levels. The foundations of the body plan are laid throughout the first days of post-implantation development as embryonic stem cells undergo symmetry breaking and initiate lineage specification, in a process that coincides with a global morphological reorganization of the embryo. Here, we review experimental models and how they have shaped our current understanding of the post-implantation mammalian embryo.
Publication types
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Historical Article
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Lineage*
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Cells, Cultured
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Embryo Research* / history
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Embryo, Mammalian / cytology
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Embryo, Mammalian / metabolism
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Embryo, Mammalian / physiology*
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Gene Expression Regulation, Developmental
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Gestational Age
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History, 20th Century
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History, 21st Century
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Human Embryonic Stem Cells / metabolism
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Human Embryonic Stem Cells / physiology*
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Humans
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Mice
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Morphogenesis*
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Mouse Embryonic Stem Cells / metabolism
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Mouse Embryonic Stem Cells / physiology*
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Signal Transduction
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Stem Cell Research* / history